- Chemical Name 1-propyl-3-(p-tolylsulphonyl)urea
- CAS No. 24570-88-5
- Contact Us Inquiry
Quality Manufacturer Supply High Purity 99% 1-propyl-3-(p-tolylsulphonyl)urea 24570-88-5 with Reasonable Price
- Molecular Formula: C11H16 N2 O3 S
- Molecular Weight: 256.326
- Melting Point: 151-152 °C
- PKA: 5.26±0.10(Predicted)
- PSA： 87.14000
- Density: 1.21g/cm3
- LogP: 3.06900
1-propyl-3-(p-tolylsulphonyl)urea(Cas 24570-88-5) Usage
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Mechanism of action |
Inhibits thyroperoxidase PTU works by inhibiting the enzyme thyroperoxidase, which is necessary for the production of thyroid hormone, thus preventing excessive hormone production. |
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Form and administration |
Tablet form, taken orally PTU is available as a medication in tablet form and is typically taken orally by patients. |
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Precautions |
Use under doctor's guidance, potential side effects and interactions It is important to use PTU under the guidance of a doctor, as it can have serious side effects and interactions with other medications. |
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General Description |
1-propyl-3-(p-tolylsulphonyl)urea is a chemical compound with the molecular formula C11H16N2O3S. It is also known as PTU or 6-propyl-2-thiouracil and is used in medicine to treat hyperthyroidism. PTU works by preventing the thyroid gland from producing excessive amounts of thyroid hormone. It accomplishes this by inhibiting the enzyme thyroperoxidase, which is necessary for the production of thyroid hormone. PTU is available as a medication in tablet form and is typically taken orally. It is important to use PTU under the guidance of a doctor, as it can have serious side effects and interactions with other medications. |
InChI:InChI=1/C11H16N2O3S/c1-3-8-12-11(14)13-17(15,16)10-6-4-9(2)5-7-10/h4-7H,3,8H2,1-2H3,(H2,12,13,14)
24570-88-5 Relevant articles
A facile synthesis of sulfonylureas: Via water assisted preparation of carbamates
Tanwar, Dinesh Kumar,Ratan, Anjali,Gill, Manjinder Singh
, p. 4992 - 4999 (2017/07/11)
A novel and simple approach to the synth...
Design and development of sulfonylurea derivatives as zinc metalloenzyme modulators
Hadianawala, Murtuza,Datta, Bhaskar
, p. 8923 - 8929 (2016/02/05)
Sulfonamide derivatives are an important...
Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas
Tan, Davin,?trukil, Vjekoslav,Mottillo, Cristina,Fri??i?, Tomislav
supporting information, p. 5248 - 5250 (2014/05/06)
We demonstrate the first application of ...
Lewis Acid Catalysed Preparation of some Carbamates and Sulphonylureas. Application to the Determination of Enantiomeric Purity of Chiral Alcohols
Irie, Hiroshi,Nishimura, Masataka,Yoshida, Morihiro,Ibuka, Toshiro
, p. 1209 - 1210 (2007/10/02)
Lewis acids such as boron trifluoride-di...
24570-88-5 Process route
-
-
110-78-1
Propyl isocyanate
-
-
70-55-3
toluene-4-sulfonamide
-
-
24570-88-5
4-methyl-N-( propylcarbamoyl)benzenesulfonamide
| Conditions | Yield |
|---|---|
|
With
copper(l) chloride;
In
nitromethane;
at 20 ℃;
for 2h;
Milling;
|
86%
|
|
With
boron trifluoride diethyl etherate;
In
diethyl ether;
Ambient temperature;
|
68%
|
|
With
sodium hydroxide;
|
-
-
107-10-8,42939-71-9
propylamine
-
-
917-61-3
sodium isocyanate
-
-
98-59-9
p-toluenesulfonyl chloride
-
-
24570-88-5
4-methyl-N-( propylcarbamoyl)benzenesulfonamide
| Conditions | Yield |
|---|---|
|
With
pyridine;
In
acetonitrile;
at 20 ℃;
for 5h;
|
53%
|
24570-88-5 Upstream products
-
51506-31-1
N-(allylcarbamoyl)-4-methylbenzenesulfonamide
-
110-78-1
Propyl isocyanate
-
70-55-3
toluene-4-sulfonamide
-
623-95-0
1,3-dipropylurea
24570-88-5 Downstream products
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1888-33-1
N-acetyl-(4-methylbenzene)sulfonamide