- Chemical Name Quinolin-2-amine
- CAS No. 580-22-3
- Contact Us Inquiry
Reliable Quality Quinolin-2-amine 580-22-3 Hot Sale with Chinese Manufacturer
- Molecular Formula: C9H8N2
- Molecular Weight: 144.176
- Appearance/Colour: colorless to light yellow liquid
- Vapor Pressure: 0.000851mmHg at 25°C
- Melting Point: 125 °C
- Refractive Index: 1.7080 (estimate)
- Boiling Point: 304.9 °C at 760 mmHg
- PKA: 3.43(at 20℃)
- Flash Point: 163.6 °C
- PSA： 38.91000
- Density: 1.21 g/cm3
- LogP: 2.39820
Quinolin-2-amine(Cas 580-22-3) Usage
|
Synthesis Reference(s) |
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189yTetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2 |
|
Safety Profile |
Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx. |
InChI:InChI=1/C9H8N2/c10-9-6-5-7-3-1-2-4-8(7)11-9/h1-6H,(H2,10,11)/p+1
580-22-3 Relevant articles
-
Tsuchiya et al.
, p. 1856,1860 (1977)
-
-
Bergstrom
, p. 1748,1750 (1934)
-
-
Luthy et al.
, p. 322,325, 326 (1949)
-
Hypervalent iodine mediated oxidative radical amination of heteroarenes under metal-free conditions
Zhao, Feng,Sun, Ting,Sun, Hefeng,Xi, Gaolei,Sun, Kai
, p. 3132 - 3135 (2017)
A metal-free, PhI(OCOCF3)2-mediated C[sb...
Site-Selective Deoxygenative Amination of Azine N-Oxides with Carbodiimides under Catalyst-, Activator-, Base-, and Solvent-Free Conditions
Sarmah, Bikash Kumar,Konwar, Monuranjan,Das, Animesh
, p. 10762 - 10772 (2021/07/31)
An operationally simple method for synth...
Solvent-Dependent Cyclization of 2-Alkynylanilines and ClCF2COONa for the Divergent Assembly of N-(Quinolin-2-yl)amides and Quinolin-2(1 H)-ones
Wang, Ya,Zhou, Yao,Ma, Xingxing,Song, Qiuling
, p. 5599 - 5604 (2021/08/01)
Herein, we present an expedient Cu-catal...
Catalyst-free synthesis of substituted pyridin-2-yl, quinolin-2-yl, and isoquinolin-1-yl carbamates from the corresponding hetaryl ureas and alcohols
Baykov, Sergey V.,Boyarskaya, Irina A.,Boyarskiy, Vadim P.,Geyl, Kirill K.,Kasatkina, Svetlana O.
, p. 6059 - 6065 (2021/07/21)
A novel catalyst-free synthesis ofN-pyri...
Copper and L-(?)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air
Bao, Xuefei,Chen, Guoliang,Dong, Jinhua,Du, Fangyu,Li, Hui,Liang, Xinjie,Wu, Ying,Zhang, Yongsheng
supporting information, (2020/08/03)
L-(?)-Quebrachitol, a natural product ob...
580-22-3 Process route
-
-
2-Azido-1-ethylchinolinium-tetrafluoroborat
-
-
580-22-3
2-aminoquinoline
-
-
54677-32-6
1-Ethyl-1,2-dihydro-2-iminochinolin
-
-
53761-50-5
1-Ethyl-1,2-dihydrochinolin-2-on
-
-
2814-57-5
1-ethylchinolin-2(1H)-on-azin
| Conditions | Yield |
|---|---|
|
With
tetrafluoroboric acid;
In
water;
for 0.5h;
Irradiation;
|
47.3%
6.1 % Spectr. 30.7% 11.7% |
|
With
tetrafluoroboric acid;
In
water;
for 0.5h;
Mechanism;
Irradiation;
|
3.2%
6.1 % Spectr. 11.7% 30.7% |
-
-
2005-43-8
2-bromoquinoline
-
-
580-22-3
2-aminoquinoline
| Conditions | Yield |
|---|---|
|
With
copper(I) oxide; 1-D-O-Methyl-chiro-inositol; ammonia; sodium hydroxide;
In
water;
at 100 ℃;
for 12h;
|
85%
|
|
With
copper acetylacetonate; potassium phosphate; ammonia;
In
N,N-dimethyl-formamide;
at 90 ℃;
for 24h;
chemoselective reaction;
Glovebox;
Autoclave;
|
70%
|
|
Multi-step reaction
with
2
steps
1: 76 percent / t-BuONa, DPPF / (DPPF)PdCl2
/ tetrahydrofuran / 3 h / 80 °C
2: 71 percent / BF3
*OEt2
/ 10percent Pd-C / ethanol / Heating
With
1,1'-bis-(diphenylphosphino)ferrocene; boron trifluoride diethyl etherate; sodium t-butanolate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal;
In
tetrahydrofuran; ethanol;
|
580-22-3 Upstream products
-
91-22-5
quinoline
-
612-62-4
2-Chloroquinoline
-
15793-77-8
2-hydrazinoquinoline
-
58106-57-3
(E)-3-(2-aminobenzene)acrylonitrile
580-22-3 Downstream products
-
33357-46-9
N-(quinolin-2-yl)benzamide
-
91045-63-5
3-[2]quinolylamino-2-cyano-acrylic acid ethyl ester
-
108999-35-5
N -[2]quinolyl-N '-phenyl-triazene
-
855762-81-1
[2]quinolyl-picryl-amine
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